Instradent Xenograft

Reliable bone volume 1–9

Similar to human bone, the Instradent® XenoGraft is a Deproteinized Bovine Bone Mineral (DBBM) with low cristallinity, high porosity and an optimal balance of calcium and phosphate designed to  achievereliable bone volume in guided bone regeneration ultimately achieving esthetic results.


  • Optimal balance of calcium and phosphatecomparable to human bone.
  • Apatite structure deproteinized, delipidized, and sterilized via gamma irradiation.


  • Consistent particle size creating a predictable scaffold with a favorable tactile feel when drilling.
  • Slow resorption rate helping to achieve long term volume.


  • Low crystallinity providing a favorable surface to which new bone can adhere.
  • High porosity supporting the osteo-conduction for having a structural scaffold for vascular ingrowth and bone formation


  • Can be mixed with either autogenous or allograft bone.
  • Combine with the Instradent Membrane to maintain ideal space and long-term cell occlusion for maximizing bone volume.

Processing assures biocompatibility

Instradent® XenoGraft is methodically processed from bovine bone and extensively tested to eliminate antigenicity and provide a favorable  environment for new bone growth. Indeed, the granules have been treated at 600°C to achieve a low crystallinity, high content of carbonate ions, and porous structure which showed a better osteoconductivity comparing to granules treated with a higher temperature.3


The Instradent® XenoGraft is comparable to the standard DBBM with a low cristalinityand similar particles size and porosity. Additionally, the Instradent® XenoGraft provides a comparable Ca/P ratio to the human bone for an optimal biocompatibility and has consistent particle size for having the reliable framework for new bone growth and for achieving bone volume.

The Instradent® XenoGraft shows in clinical trial or in a preclinical study its successful outcomes in Guided Bone Regeneration (GBR) improving key clinical parameters.


1. A study on the safety and efficacy of bovine bone-derived bone graft material (OCS-B). J Korean Acad Periodontol. 2005 Jun;35(2):335-343.

2. Evaluation on the bone regenerative capacity of deproteinized bovine bone-derived bone graft material (OCS-B). The Journal of the Korean Dental Association. Vol.44 No.6, 2006.6, 359-366.

3. Effect of Heat-Treatment Temperature on the Osteoconductivity of the Apatite Derived from Bovine Bone, Key Engineering Materials Vols. 309-311 (2006) pp 41-44

4. Bone reaction to bovine hydroxyapatite grafted in the mandibular defects of beagle dogs. J Korean Acad Periodontol. 2006;36:39-49.

5. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone graft material (OCB-B®). Clinical and histologic findings in human. The Journal of the Korean Dental Association. 2007; 45(8): 491-499.

6. Periodontal Repair on Intrabony Defects treated with Anorganic Bovine-derived XenoGraft. J Korean Acad Periodontol. 2007; 37(3): 489-496.

7. The comparative study - the regenerative effect depends on size of bone graft material in bone loss site around dental implant. J Korean Acad Periodontol. 2008;38:493-502.

8. A comparative analysis of basic characteristics 06 | Instradent productos of several deproteinized bovine bone substitutes. J Korean Acad Periodontol. 2009;39:149-156.

9. A radiographical study on the changes in height of grafting materials after sinus lift: a comparison between two types of xenogenic materials, JPeriodontal Implant Sci 2010;40:25-32

10. Comparative study of two collagen membranes for guided tissue regeneration therapy in periodontal intrabony defects: a randomized clinical trial; Young-Mi Chung, Jue-Yeon Lee, Seong-Nyum Jeong; J Periodontal Implant Sci 2014; 44:194-200

11. Biological effects of a porcine-derived collagen membrane on intrabony defects; Chang-Kyun Lee, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu, Young Ku, Chong-Pyoung Chung1, Yoon-Jeong Park, Jue-Yeon Lee; J Periodontal Implant Sci 2010;40:232-238

12. Speer DP, Chvapil M, Eskelson CD, Ulreich J. Biological effects of residual glutaraldehyde in glutaraldehyde-tanned collagen biomaterials. J Biomed Mater Res 1980;14:753-64.

13. Locci P, Calvitti M, Belcastro S, Pugliese M, Guerra M, Marinucci L, et al. Phenotype expression of gingival fibroblasts cultured on membranes used in guided tissue regeneration.J Periodontol 1997;68:857-63. 14. Datos de archivo