Predictable regeneration 10–14

Instradent® Collagen Membrane (type I) is a porous non-chemical cross-linkingporcine-derived (dermis) fibrous membrane designed to achieve predictable guided bone regeneration and tissue  regeneration.


  • Cross-linked collagen without chemicals allowing a slow and predictable barrier resorption rate from 4 to 6 months providing ideal condition for bone growth.
  • Fibrous structure enabling cell occlusion supporting bone regeneration, protecting the graft area of unwanted soft tissue infiltrations during the initial healing phase.


  • High tear resistance allowing a wide variety of fixing methods, including pins and sutures enhancing undisturbed bone regeneration site.
  • Multi-layers structured of type 1 collagen providing bone healing stability and soft tissue support.


  • Can be placed in conjunction with any bone grafting material or as a standalone solution.
  • Available in 3 different sizes.



  • Either side can be placed dry or hydrated, so not side specific.
  • Easily repositionable for precise placement.

Processing assures biocompatibility

Instradent® Collagen Membrane is meticulously manufactured from highly purified native collagen, ideal choice for the excellent  biocompatibility and capacity to enhance wound healing process. The cross-linking has been achieved without chemicals (such as  formaldehyde and glutaraldehyde) to avoid any adversely influences on surrounding tissues or leave of cytotoxic residue during the process. 12, 13


The Instradent® Collagen Membrane has a multi-layer fibrous  structure designed for acting as a cell occlusive barrier which  protects the healing site. The porous surface is designed to helps vascularization enhancing the soft and hard tissue healing.  Additionally, its high tear resistance preserves undisturbed the bone regeneration site.

The Instradent® Collagen Membrane shows in a randomized clinical trial or in a preclinicalstudy its successful outcomes in Guided Tissue
Regeneration (GTR) or in Guided Bone Regeneration (GBR) improving key clinical parameters.


1. A study on the safety and efficacy of bovine bone-derived bone graft material (OCS-B). J Korean Acad Periodontol. 2005 Jun;35(2):335-343.

2. Evaluation on the bone regenerative capacity of deproteinized bovine bone-derived bone graft material (OCS-B). The Journal of the Korean Dental Association. Vol.44 No.6, 2006.6, 359-366.

3. Effect of Heat-Treatment Temperature on the Osteoconductivity of the Apatite Derived from Bovine Bone, Key Engineering Materials Vols. 309-311 (2006) pp 41-44

4. Bone reaction to bovine hydroxyapatite grafted in the mandibular defects of beagle dogs. J Korean Acad Periodontol. 2006;36:39-49.

5. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone graft material (OCB-B®). Clinical and histologic findings in human. The Journal of the Korean Dental Association. 2007; 45(8): 491-499.

6. Periodontal Repair on Intrabony Defects treated with Anorganic Bovine-derived XenoGraft. J Korean Acad Periodontol. 2007; 37(3): 489-496.

7. The comparative study - the regenerative effect depends on size of bone graft material in bone loss site around dental implant. J Korean Acad Periodontol. 2008;38:493-502.

8. A comparative analysis of basic characteristics 06 | Instradent productos of several deproteinized bovine bone substitutes. J Korean Acad Periodontol. 2009;39:149-156.

9. A radiographical study on the changes in height of grafting materials after sinus lift: a comparison between two types of xenogenic materials, JPeriodontal Implant Sci 2010;40:25-32

10. Comparative study of two collagen membranes for guided tissue regeneration therapy in periodontal intrabony defects: a randomized clinical trial; Young-Mi Chung, Jue-Yeon Lee, Seong-Nyum Jeong; J Periodontal Implant Sci 2014; 44:194-200

11. Biological effects of a porcine-derived collagen membrane on intrabony defects; Chang-Kyun Lee, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu, Young Ku, Chong-Pyoung Chung1, Yoon-Jeong Park, Jue-Yeon Lee; J Periodontal Implant Sci 2010;40:232-238

12. Speer DP, Chvapil M, Eskelson CD, Ulreich J. Biological effects of residual glutaraldehyde in glutaraldehyde-tanned collagen biomaterials. J Biomed Mater Res 1980;14:753-64.

13. Locci P, Calvitti M, Belcastro S, Pugliese M, Guerra M, Marinucci L, et al. Phenotype expression of gingival fibroblasts cultured on membranes used in guided tissue regeneration.J Periodontol 1997;68:857-63. 14. Datos de archivo